The endocannabinoid system (ECS) and the autonomic nervous system (ANS) are crucial for maintaining bodily homeostasis, yet their interaction remains underexplored. We present the first clinical case in which the osteopathic CV4 technique modulated both systems in a 53-yearold patient with habitual cannabis use, comorbidities, and sleep disorders. Following treatment, the patient reported reduced THC consumption, improved sleep quality, and enhanced overall well-being, as confirmed by the Pittsburgh Sleep Quality Index (PSQI) and SF-36 questionnaires. This innovative case demonstrates how non-invasive techniques can influence complex physiological systems, opening new therapeutic avenues for conditions such as anxiety, chronic pain, and sleep disturbances. Our goal is to expand this research with larger studies and advanced tools, inspiring novel integrative approaches. This work represents a significant step forward in integrative medicine, bridging science and clinical practice in a promising way.

Active in the field of research, he has published scientific articles in the fields of osteopathy and kinesiology in indexed journals, contributing to the scientific literature in these areas. He collaborates with specialized journals and participates as a peer reviewer to ensure the quality of published studies. He is a member of the research staff at Omicron Beta Research, where he contributes to innovative projects in the fields of motor sciences and manual therapies. Additionally, he collaborates with the University of Medicine and Surgery of Tor Vergata, participating in studies and academic activities that promote the integration of research and clinical practice. His academic and professional path is oriented toward an evidence-based approach, aiming to improve the effectiveness of treatments and contribute to the advancement of osteopathic and kinesiological disciplines. His research activities and collaboration with prestigious institutions reflect a constant commitment to promoting scientific knowledge and advanced clinical applications.