Sara Ferrigno
University of Rome Tor Vergata, ItalyTitle: Assessment of microvascular involvement in lupus nephritis patients by retinal OCT-angiography and kidney biopsies
Abstract
Objectives
Ocular and renal microvascular damage in Lupus Nephritis (LN) share similar physiopathological pathways that have investigated using traditional fundus examination and high-resolution color electroretinography. Optical coherence tomography angiography (OCTA) is a recent, non-invasive technique for imaging the microvasculature of retina and choroid. Aim of the study was to investigate through OCTA analysis the relationship between retinal microvasculature alterations and renal function and histologic features.
Methods
Systemic Lupus Erythematosus (SLE) patients with LN, SLE without renal involvement and healthy controls were recruited and accomplished an ophthalmological evaluation, including OCTA. SLE-LN patients underwent a rheumatological evaluation, including disease-related clinical and laboratory features collection and kidney biopsy examination.
Results
This cross-sectional study enrolled forty-six eyes of 23 LN patients, thirty-two eyes of 16 SLE patients and forty-two eyes of 21 controls. Thirteen SLE-LN patients (56.5%) displayed lupus retinopathy, 10 at moderate (77%) and 3 at severe stage (23%) by fundus oculi examination.
Analysis of OCTA data showed with high/moderate accuracy a reduction of retinal capillary vessel density in both SLE and SLE-LN patients compared to controls in superficial and deep plexi. A reduction in fovea thickness and an increase in foveal avascular zone were also detected. OCTA
data of LN patients correlated with LN duration, disease activity, kidney function and the presence of LN-vascular lesions at kidney biopsy.
Conclusions
Our results suggest the role of OCTA in early detection of systemic vascular involvement in SLE-LN patients and related kidney functional-histological impairment.
Biography
Sara Ferrigno is a resident doctor in Rheumatology attending the last year at the University of Rome Tor Vergata. During the last years, her research work focused mainly on connective tissue diseases, particularly SLE.
She attended as presenting author at the Lupus&CORA congress in 2021, at the Italian Society for Rheumatology congress for two consecutive years (2021-2022) and at the EULAR congress in 2022. She also received two awards for young researchers from the Italian society of Rheumatology (2021-2022).
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