Sania Valieva
Morozov Children’s City Clinical Hospital, Russian FederationTitle: Chronic recurrent multifocal osteomyelitis in children: a single center 10-year experience
Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic autoinflammatory disease that primarily affects the skeleton in the absence of an infectious etiology in children and adolescents. We report demographic, clinical and laboratory characteristics of a single center cohort of CRMO patients (33) in Morozov Children’s City Clinical Hospital between 2011 and 2021. 25 (75%) were female. Median age of symptoms onset was 9 [7;13] years. Median delay in diagnosis was 12 months. All patients had bone pain as an initial symptom; fever has been present in 12 patients (63%). Joints involvement was observed in 22 patients (67%). All of the patients had multifocal bone lesions. Eleven patients (33%) also had sacroiliitis. Other organs involvement was observed 7 patients presented with palmoplantar pustulosis and psoriasis. Histopathological diagnosis was confirmed in 24 (73%) patients. Mean erythrocyte sedimentation rate (ECR) was 43 mm/h and C-reactive protein (CRP) - 27 mg/L. 23 (69,6%) patients had immunological activity. CRMO remains a rare diagnosis. From our experience, most of the patients had delay in diagnosis.
Biography
Sania Valieva has completed his PHD in 2014. Until 2018, she was the head of the Scientific Center for Children's Health, Moscow. Currently working in the Morozov Children's City Hospital as a rheumatologist, deputy chief medical officer.
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