Virtual Conference

Harshita Nadella

Nova Southeastern University , United States

Title: The overlap of diabetes and osteoarthritis in American populations


Diabetes mellitus (DM), a condition in which the body’s ability to produce insulin is impaired, and osteoarthritis (OA), a painful degeneration of joint cartilage, are both serious conditions that affect millions of people in the United States (U.S.). The purpose of this paper is to find a connection, if any, between diabetes and osteoarthritis and if either condition can predispose an individual to the other. Not only can this review help to explain the co-existence of these two diseases, but it can also be used to investigate a cure for patients in the future. After preliminary searches were done on PubMed, results were narrowed using specific keywords and similar risk factors among the two diseases. It was found that these two conditions are interrelated due to oxidative stress and pro-inflammatory cytokines. Seeing the high risk of developing one of these conditions and that obesity, one of the biggest risk factors for both diabetes and osteoarthritis, is at an all-time high in this country, a possible connection between the two of these diseases is very prevalent to explore. This information can be used to help correlate not only a better-targeted treatment but also lead to future research into why obesity is one of the biggest risk factors for both conditions.


Harshita Nadella is a medical student studying at the Kiran C. Patel College of Osteopathic Medicine part of Nova Southeastern University located in South Florida to earn her Doctor of Osteopathic Medicine (D.O.) degree. She is from Northern Virginia originally and completed her Bachelor of Science degree at Cornell University in Ithaca, New York. Highly motivated and interested in the impacts of both osteoarthritis and diabetes, she reached out to Dr. Mark Kesselman, Professor, Chair of the Department of Internal Medicine, and Chief of the Rheumatology Division at NSU-KPCOM. Together, they attempt to shed light on the possible immunological connections between the two disease processes. She hopes to educate medical colleagues about this vital connection and incorporate this information into the care of both diabetic and arthritis patients.